European guidance for the diagnosis and management of osteoporosis in postmenopausal women

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Recently, there have been significant advances in the field of osteoporosis management. A new, simple, WHO-validated method of assessing fracture risk has been developed, as have new treatments that have been shown to significantly reduce the risk of fractures at vulnerable sites. Against this background, the European Society for Clinical and Economic Evaluation of Osteoporosis and Osteoarthritis (ESCEO), in collaboration with the IOF, has developed new guidelines . J. A. Kanis, N. Burlet, C. Cooper , P. D. Delmas, J.-Y. Reginster, F. Borgstrom, R. Rizzoli. On behalf of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) Osteoporos Int (2008) 19:399-428

ESCEO Pocket Guidelines


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European Society for Clinical and Economic Evaluation of Osteoporosis and Osteoarthritis (ESCEO), in collaboration with the IOF, has developed new guidelines (see below) and has published a practical summary in "pocket" format in five languages, available here. Please note that the management algorithms are based on a health economic analysis applied to the epidemiology of fracture in the UK and may require adaptation for other European countries. English
German
Spanish
French
Italian

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Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw F. Marini, P. Tonelli, L. Cavalli, T. Cavalli, L. Masi, A. Falchetti, M. L. Brandi
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What is a good patient reported outcome after total hip replacement? N.K. Arden, A. Kiran, A. Judge, L.C. Biant, M.K. Javaid, D.W. Murray, A.J. Carr, C. Cooper, R.E. Field
Does birthweight predict bone mass in adulthood? A systematic review and meta-analysis. J. Baird, M. A. Kurshid, M. Kim, N. Harvey, E. Dennison, C. Cooper
Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast J. K. Cleal, J. D. Glazier, G. Ntani, S. R. Crozier, P. E. Day, N. C. Harvey, S. M. Robinson, C. Cooper, K. M. Godfrey, M. A. Hanson, R. M. Lewis
Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal children Z.A. Cole, N.C. Harvey, M. Kim, G. Ntani, S.M. Robinson, H.M. Inskip, K.M. Godfrey, C. Cooper, E.M. Dennison, The Southampton Women's Survey Study Group
Objective measures of physical capability and subsequent health: a systematic review R. Cooper, D. Kuh, C. Cooper, C. R. Gale, D. A. Lawlor, F. Matthews, R. Hardy, The Falcon and Halcyon Study Teams
Secular trends in the incidence of hip and other osteoporotic fractures C. Cooper, Z. A. Cole, C. R. Holroyd, S. C. Earl, N. C. Harvey, E. M. Dennison, L. J. Melton, S. R. Cummings, J. A. Kanis, The IOF CSA Working Group on Fracture Epidemiology
Epigenetic influences in the developmental origins of osteoporosis C. Holroyd, N. Harvey, E. Dennison, C. Cooper
Growth in childhood predicts hip fracture risk in later life M. K. Javaid, J. G. Eriksson, E. Kajantie, T. Forsén, C. Osmond, D. J. P. Barker, C. Cooper
Coordinator-based systems for secondary prevention in fragility fracture patients D. Marsh, K. Akesson, D. E. Beaton, E. R. Bogoch, S. Boonen, M.-L. Brandi, A. R. McLellan, P. J. Mitchell, J. E. M. Sale, D. A. Wahl, IOF CSA Fracture Working Group
Association of vitamin D status with knee pain and radiographic knee osteoarthritis S. Muraki, E. Dennison, K. Jameson, B.J. Boucher, T. Akune, N. Yoshimura, A. Judge, N.K. Arden, K. Javaid, C. Cooper
Use of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control study S. Pouwels, A. Lalmohamed, P. Souverein, C. Cooper, B. J. Veldt, H. G. Leufkens, A. de Boer, T. van Staa, F. de Vries
Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysis D. Prieto-Alhambra, M. K. Javaid, A. Judge, J. Maskell, A. Kiran, C. Cooper, N. K. Arden
Changes in hip fracture rate before and after total knee replacement due to osteoarthritis: a population-based cohort study D. Prieto-Alhambra, M. K. Javaid, J. Maskell, A. Judge, M. Nevitt, C. Cooper, N. K. Arden
Fracture Risk Before and After Total Hip Replacement in Patients With Osteoarthritis D. Prieto-Alhambra, M. K. Javaid, A. Judge, J. Maskell, A. Kiran, F. de Vries, C. Cooper, N. K. Arden
Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report R. Rizzoli, K. Akesson, M. Bouxsein, J. A. Kanis, N. Napoli, S. Papapoulos, J.-Y. Reginster, C. Cooper
Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW) E. S. Siris, S. Gehlbach, J. D. Adachi, S. Boonen, R. D. Chapurlat, J. E. Compston, C. Cooper, P. Delmas, A. Díez-Pérez, F. H. Hooven, A. Z. LaCroix, J. C. Netelenbos, J. Pfeilschifter, M. Rossini, C. Roux, K. G. Saag, P. Sambrook, S. Silverman, N. B. Watts, A. Wyman, S. L. Greenspan
Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards S. Vasikaran, R. Eastell, O. Bruyère, A. J. Foldes, P. Garnero, A. Griesmacher, M. McClung, H. A. Morris, S. Silverman, T. Trenti, D. A. Wahl, C. Cooper, J. A. Kanis, for the IOF-IFCC Bone Marker Standards Working Group
Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study A. K. Wills, S. Black, R. Cooper, R. J. Coppack, R. Hardy, K. Remmes Martin, C. Cooper, D. Kuh
A FRAX® model for the assessment of fracture probability in Belgium H. Johansson, J. A. Kanis, E. V. McCloskey, A. Odén, J.-P. Devogelaer, J.-M. Kaufman,A. Neuprez, M. Hiligsmann, O. Bruyere, J.-Y. Reginster
Adverse Reactions and Drug-Drug Interactions in the Management of Women with Postmenopausal Osteoporosis R. Rizzoli, J.-Y. Reginster, S. Boonen, G. Bréart, A. Diez-Perez, D. Felsenberg, J.-M. Kaufman, J. A. Kanis, C. Cooper
Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies P. Miossec, C. L. Verweij, L. Klareskog, C. Pitzalis, A. Barton, F. Lekkerkerker, S. Reiter, A. Laslop, F. Breedveld, E. Abadie, B. Flamion, W. Dere, S. Mpofu, N. Goel, D. Ethgen, B. Mitlak, S. Ormarsdóttir, R. Rao, Y. Tsouderos, J.-Y. Reginster; on behalf of the Group for the Respect of Ethics and Excellence in Science (GREES)
The potential impact of new National Osteoporosis Foundation guidance on treatment patterns B. Dawson-Hughes, A. C. Looker,A. N. A. Tosteson, H. Johansson, J. A. Kanis, L. J. Melton III
Automatic Human Knee Cartilage Segmentation From 3-D Magnetic Resonance Images P. Dodin, J.-P. Pelletier, J. Martel-Pelletier, F. Abram
Development and validation of a disease model for postmenopausal osteoporosis A. Gauthier, J. A. Kanis, M. Martin, J. Compston, F. Borgström, C. Cooper, E. McCloskey; On behalf of the Committee of Scientific Advisors, International Osteoporosis Foundation
FRAX - modell för att beräkna 10-årsrisken för fraktur H. Johansson, J. A. Kanis, Ö. Ljunggren, O. Ström, O. Svensson, D. Mellström
Osteoporosis J. A. Kanis
Case finding for the management of osteoporosis with FRAX®-assessment and intervention thresholds for the UK J. A. Kanis, E. V. McCloskey, H. Johansson, O. Ström, F. Borgström, A. Oden, National Osteoporosis Guideline Group
Guidance for the adjustment of FRAX according to the dose of glucocorticoids J. A. Kanis, H. Johansson, A. Oden, E. V. McCloskey
Development and use of FRAX® in osteoporosis J. A. Kanis, E. V. McCloskey, H. Johansson, A. Oden, O. Strom, F. Borgstrom
Osteoporosis - Clinical Review J. A. Kanis, E. V. McCloskey
Towards a diagnostic and therapeutic consensus in male osteoporosis J. A. Kanis, G. Bianchi, J. P. Bilezikian, J.-M. Kaufman, S. Khosla, E. Orwoll, E. Seeman
Targeting subchondral bone for treating osteoarthritis: what is the evidence? S. Kwan Tat, D. Lajeunesse, J.-P. Pelletier, J. Martel-Pelletier.
Spine-hip discordance and fracture risk assessment: a physician-friendly FRAX enhancement W. D. Leslie, L. M. Lix, H. Johansson, A. Oden, E. McCloskey, J. A. Kanis
Independent Clinical Validation of a Canadian FRAX Tool: Fracture Prediction and Model Calibration W. D. Leslie, L. M. Lix, H. Johansson, A. Oden, E. V. McCloskey, J. A. Kanis for the Manitoba Bone Density Program
Hip fracture risk in older US adults by treatment eligibility status based on new National Osteoporosis Foundation guidance A. C. Looker, B. Dawson-Hughes, A. N. A. Tosteson, H. Johansson, J. A. Kanis, L. J. Melton III
Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis J.-P. Pelletier, J.-P. Raynauld, J. Caron, F. Mineau, F. Abram, M. Dorais, B. Haraoui, D. Choquette, J. Martel-Pelletier
Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation J.-P. Raynauld, J. Martel-Pelletier, B. Haraoui, D. Choquette, M. Dorais, L. M. Wildi, F. Abram, J.-P. Pelletier; for the Canadian Licofelone Study Group
Adverse Reactions and Drug-Drug Interactions in the Management of Women with Postmenopausal Osteoporosis R. Rizzoli, J.-Y. Reginster, S. Boonen, G. Bréart, A. Diez-Perez, D. Felsenberg, J.-M. Kaufman, J. A. Kanis, C. Cooper
Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts S. Kwan Tat, J.-P. Pelletier, F. Mineau, J. Caron, J. Martel-Pelletier
hondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI L. M. Wildi, J.-P. Raynauld, J. Martel-Pelletier, A. Beaulieu, L. Bessette, F. Morin, F. Abram, M. Dorais, J.-P. Pelletier
Assessment of health claims in the field of bone: a view of the Group for the Respect of Ethics and Excellence in Science (GREES) O. Bruyère, R. Rizzoli, V. Coxam, B. Avouac, T. Chevalier, V. Fabien-Soulé, J. A. Kanis, J.-M. Kaufman, Y. Tsouderos, J.-Y. Reginster
The need for a transparent, ethical, and successful relationship between academic scientists and the pharmaceutical industry: a view of the Group for the Respect of Ethics and Excellence in Science (GREES) O. Bruyère, J. A. Kanis, M.-E. Ibar-Abadie, N. Alsayed, M. L. Brandi, N. Burlet, D. L. Cahall, A. Chines, J.-P. Devogelaer, W. Dere, N. Goel, N. Hughes, J.-M. Kaufman, S. Korte, B. H. Mitlak, D. Niese, R. Rizzoli, L. C. Rovati, J.-Y. Reginster
Loading and Skeletal Development and Maintenance P. Bergmann, J. J. Body, S. Boonen, Y. Boutsen, J.-P. Devogelaer, S. Goemaere, J. Kaufman, J.-Y. Reginster, S. Rozenberg
Recommendations for an update of 2003 European regulatory requirements for registration of drugs to be used in the treatment of RA J. S. Smolen, M. Boers, E. C. Abadie, F. C. Breedveld, P. Emery, T. Bardin, N. Goel, D. J. Ethgen, B. P. Avouac, W. H. Dere, P. Durez, M. Matucci-Cerenic, B. Flamion, A. Laslop
Medication Compliance and Persistence: Terminology and Definitions J. A. Cramer, A. Roy, A. Burrell, C. J. Fairchild, M. J. Fuldeore, D. A. Ollendorf, P. K. Wong
A Competing Risks Prescription Refill Model of Compliance and Persistence T. I. Barron, K. Bennett, J. Feely
Evidence-based guidelines for the pharmacological treatment of postmenopausal osteoporosis: a consensus document by the Belgian Bone Club J.-J Body, P. Bergmann, S. Boonen, Y. Boutsen, J.-P. Devogelaer, S. Goemaere, J.-M. Kaufman, S. Rozenberg, J.-Y. Reginster
Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis R. Rizzoli, N. Burlet, D. Cahall, P. D. Delmas, E. F. Eriksen, D. Felsenberg, J. Grbic, M. Jontell, R. Landesberg, A. Laslop, M. Wollenhaupt, S. Papapoulos, O. Sezer, M. Sprafka, J.-Y. Reginster
The role of calcium and vitamin D in the management of osteoporosis R. Rizzoli, S. Boonen, M.-L. Brandi, N. Burlet, P. Delmas, J.-Y. Reginster
European regulatory perspectives for innovative therapies S. Ormarsdottir, J.-Y. Reginster, E. Abadie
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system O. Bruyère, N. Burlet, P. D. Delmas, R. Rizzoli, C. Cooper and J.-Y. Reginster
Recommendations for the registration of agents for prevention and treatment of glucocorticoid-induced osteoporosis: an update from the Group for the Respect of Ethics and Excellence in Science J. Compston, D.M. Reid, J. Boisdron, M.-L. Brandi, N. Burlet, D. Cahall, P.D. Delmas, W. Dere, J.-P. Devogelaer, L.A. Fitzpatrick, B. Flamion, N. Goel, S. Korte, A. Laslop, B. Mitlak, S. Ormarsdottir, J. Ringe, R. Rizzoli, Y. Tsouderos, T. Van Staa, J.-Y. Reginster
Loss of hip bone mineral density over time is associated with spine and hip fracture incidence in osteoporotic postmenopausal women O. Bruyere, A. R. Varela, S. Adami, J. Detilleux, V. Rabenda, M. Hiligsmann, J.-Y. Reginster
Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity P. Musette, M. L. Brandi, P. Cacoub, J. M. Kaufman, R. Rizzoli, J.-Y. Reginster
Management of osteoporosis in the elderly R. Rizzoli, O. Bruyere, J. B. Cannata-Andia, J.-P. Devogelaer, G. Lyritis, J. D. Ringe, B. Vellas, J.-Y. Reginster
Post-fracture management of patients with hip fracture: a perspective O. Bruyere, M.-L. Brandi, N. Burlet, N. Harvey, G. Lyritis, H. Minne, S. Boonen, J.-Y. Reginster, R. Rizzoli and K. Akesson
European guidance for the diagnosis and management of osteoporosis in postmenopausal women J. A. Kanis, N. Burlet, C. Cooper, P. D. Delmas, J.-Y. Reginster, F. Borgstrom, R. Rizzoli
Adherence to bisphosphonates therapy and hip fracture risk in osteoporotic women V. Rabenda, R. Mertens, V. Fabri, J. Vanoverloop, F. Sumkay, C. Vannecke, A. Deswaef, G. A. Verpooten, J.-Y. Reginster
Adherence to treatment of osteoporosis: a need for study F. Lekkerkerker, J. A. Kanis, N. Alsayed, G. Bouvenot, N. Burlet, D. Cahall, A. Chines, P. Delmas, R.-L. Dreiser, D. Ethgen, N. Hughes, J.-M. Kaufman, S. Korte, G. Kreutz, A. Laslop, B. Mitlak, V. Rabenda, R. Rizzoli, A. Santora, R. Schimmer, Y. Tsouderos, P. Viethel, J.-Y. Reginster
Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis J. Goldhahn, W. H. Scheele, B. Mitlak, E. Abadie, P. Aspenberg, P. Augat, M.-L. Brandi, N. Burlet, A. Chines, P. D. Delmas, I. Dupin-Roger, D. Ethgen, B. Hanson, F. Hartl, J. Kanis, R. Kewalramani, A. Laslop, D. Marsh, S. Ormarsdottir, R. Rizzoli, A. Santora, G. Schmidmaier, M. Wagener, J.-Y. Reginster
Critical Issues in Translational and Clinical Research for the Study of New Technologies to Enhance Bone Repair J. Goldhahn, B. Mitlak P. Aspenberg, J. Kanis, R. Rizzoli, J.-Y. Reginster
Low Incidence of Anti-Osteoporosis Treatment After Hip Fracture V. Rabenda, J. Vanoverloop, V. Fabri, R. Mertens, F. Sumkay, C. Vannecke, A. Deswaef, G. A. Verpooten, J.-Y. Reginster
Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence V. Rabenda, M. Hiligsmann, J.-Y. Reginster
Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures V. Rabenda, J.-Y. Reginster
Recommendations for an update of the current (2001) regulatory requirements for registration of drugs to be used in the treatment of osteoporosis in postmenopausal women and in men J.-Y. Reginster, E. Abadie, P. Delmas, R. Rizzoli, W. Dere, P. der Auwera, B. Avouac, M.-L. Brandi, A. Daifotis, A. Diez-Perez, G. Calvo, O. Johnell, J.-M. Kaufman, G. Kreutz, A. Laslop, F. Lekkerkerker, B. Mitlak, P. Nilsson, J. Orloff, M. Smillie, A. Taylor, Y. Tsouderos, D. Ethgen, B. Flamion
Therapeutic Adherence with Bisphosphonates in the Treatment of Osteoporosis V. Rabenda, J.-Y. Reginster
Loss of hip bone mineral density over time is associated with spine and hip fracture incidence in osteoporotic postmenopausal women O. Bruyere, A. R. Varela, S. Adami, J. Detilleux,V. Rabenda, M. Hiligsmann, J.-Y. Reginster

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